Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Respiratory failure
ADR ID BADD_A03813
ADR Hierarchy
14      Metabolism and nutrition disorders
14.01      Acid-base disorders
14.01.04      Respiratory acidoses
14.01.04.003      Respiratory failure
22      Respiratory, thoracic and mediastinal disorders
22.02      Respiratory disorders NEC
22.02.06      Respiratory failures (excl neonatal)
22.02.06.002      Respiratory failure
Description A disorder characterized by impaired gas exchange by the respiratory system resulting in hypoxia and a decrease in oxygenation of the tissues that may be associated with an increase in arterial levels of carbon dioxide. [CTCAE] Failure to adequately provide oxygen to cells of the body and to remove excess carbon dioxide from them. (Stedman, 25th ed) [MeSH]
MedDRA Code 10038695
MeSH ID D012131; D012131; D012131
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE)
Synonym
Failure respiratory | Other pulmonary insufficiency, not elsewhere classified | Pulmonary insufficiency following trauma and surgery | Respiration failure | Respiratory failure | Respiratory failure (excl neonatal) | Respiratory insufficiency | Ventilatory failure | Pulmonary failure | Hypercapnic respiratory failure | Restrictive respiratory insufficiency | Respiratory failure aggravated | Hypoxic respiratory failure | Respiratory Insufficiency | Respiratory Failure | Respiratory Depression | Ventilatory Depression | Depressions, Ventilatory
ADR Related Proteins
Protein Name UniProt AC TTD Target ID
Not AvailableNot AvailableNot Available
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00629Dexmedetomidine0.000236%
BADD_D00630Dexmedetomidine hydrochloride--
BADD_D00648Diazepam0.000334%
BADD_D00649Diazoxide0.000646%
BADD_D00653Diclofenac--
BADD_D00668Digoxin0.000664%
BADD_D00674Diltiazem0.000120%
BADD_D00680Dimethyl fumarate--
BADD_D00686Diphenhydramine0.000593%
BADD_D00699Docetaxel0.000834%
BADD_D00701Dofetilide0.000194%
BADD_D00706Donepezil--
BADD_D00711Dornase alfa--
BADD_D00716Doxapram--
BADD_D00718Doxazosin0.000126%
BADD_D00720Doxepin0.001036%
BADD_D00723Doxorubicin0.000764%
BADD_D00730Dronedarone0.004490%
BADD_D00732Droxidopa--
BADD_D00734Duloxetine--
BADD_D00736Dutasteride0.000408%
BADD_D00759Eltrombopag--
BADD_D00761Eluxadoline--
BADD_D00765Empagliflozin--
BADD_D00775Enzalutamide--
BADD_D00782Epinephrine--
BADD_D00788Epoprostenol0.000871%
BADD_D00798Eribulin--
BADD_D00800Erlotinib--
BADD_D00809Escitalopram--
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